High-efficiency gene transfer into cardiac myocytes
نویسندگان
چکیده
منابع مشابه
Gene transfer into cardiac myocytes in vivo.
The ability to express recombinant genes in cardiac myocytes in vivo holds promise for the treatment of a number of inherited and acquired diseases of the cardiovascular system. Several groups have demonstrated recently that plasmid DNA is taken up and expressed in cardiac myocytes following injection into the left ventricular wall in vivo. Recombinant genes introduced into cardiac myocytes by ...
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Recent studies have demonstrated that cardiac and skeletal myocytes share the ability to take up and stably express plasmid DNA injected directly into myocardium or skeletal muscle in vivo. Although this is a relatively inefficient process, with less than 1% of the myocytes expressing the injected recombinant DNA, expression in these cells is stable for periods of at least 6 months. The majorit...
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among the earliest in the field, and more recently gene and cell therapies have demonstrated significant potential for the treatment of common cardiovascular problems such as refractory myocardial ischaemia and dysfunction. Accumulating preclinical studies are providing an increasingly sound scientific basis for cautious human evaluation of additional gene and cell therapy strategies. Furthermo...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1992
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/20.23.6425